Description

4,5,6,7-Tetrahydro-4-Oxo-1H-Indole-1-Carboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate with the CAS number 877170-76-8. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those with indole-based scaffolds.
• API Synthesis: Used in the multi-step production of complex Active Pharmaceutical Ingredients (APIs) for neurological and metabolic therapies.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing diverse chemical libraries in drug discovery and lead optimization.
• Process Development & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for commercial pharmaceutical manufacturing.
• Fine Chemical Synthesis: Utilized in the preparation of other specialty chemicals and complex organic molecules requiring a protected indole carboxylic acid moiety.

Basic Information

Product Name	4,5,6,7-Tetrahydro-4-Oxo-1H-Indole-1-Carboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	877170-76-8
Molecular Formula	C13H19NO3
Molecular Weight	237.29 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 4,5,6,7-tetrahydro-4-oxo-, 1,1-dimethylethyl ester; 4-Oxo-4,5,6,7-tetrahydro-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 4-oxo-4,5,6,7-tetrahydro-1H-indole-1-carboxylate; 4-Oxo-1,4,5,6,7,8-hexahydroindole-1-carboxylic acid tert-butyl ester; BOC-4-oxo-4,5,6,7-tetrahydroindole; 877170-76-8
EINECS	Contact for details

Quality Control

Our 4,5,6,7-Tetrahydro-4-Oxo-1H-Indole-1-Carboxylic Acid 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality standards are designed to meet the stringent requirements of pharmaceutical R&D and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light sources to maintain stability and purity. For long-term storage, consider using desiccants and storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.