Description

7-Bromo-4,5-Difluoro-1H-Indole is a high-value, multi-functional halogenated indole derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine and fluorine substituents on the indole core, makes it an indispensable intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine and bromine atoms can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport materials.
• Fluorinated Compound Library: An essential component for building diverse screening libraries in medicinal and combinatorial chemistry.
• Chemical Biology Probes: Utilized in the synthesis of labeled probes and tags for studying biological processes and target engagement.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl systems.

Basic Information

Item	Details
Product Name	7-Bromo-4,5-Difluoro-1H-Indole
CAS No.	877160-16-2
Molecular Formula	C8H4BrF2N
Molecular Weight	232.03 g/mol
Synonyms	7-Bromo-4,5-difluoroindole; 4,5-Difluoro-7-bromo-1H-indole; 1H-Indole, 7-bromo-4,5-difluoro-; 877160-16-2; 7-Br-4,5-F2-1H-Indole; 7-Bromo-4,5-difluoro-1H-indole; 4,5-Difluoro-7-bromoindole
EINECS	Contact for details

Quality Control

Every batch of 7-Bromo-4,5-Difluoro-1H-Indole is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.