Description

5-Methyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid ethyl ester is a high-purity, advanced pharmaceutical intermediate belonging to the indazole class of heterocyclic compounds. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, particularly in areas such as oncology and neurology.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for constructing compound libraries in drug discovery programs, particularly for kinase inhibitors and other targeted therapies.
• Organic Synthesis Building Block: Employed in multi-step synthetic routes to create complex, functionalized indazole derivatives for biological screening.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis projects requiring high-purity, specialized intermediates.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry, reaction mechanisms, and structure-activity relationships (SAR).

Basic Information

Product Name	5-Methyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid ethyl ester
CAS No.	876480-16-9
Molecular Formula	C11H16N2O2
Molecular Weight	208.26 g/mol
Synonyms	Ethyl 5-methyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate; 5-Methyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid ethyl ester; 876480-16-9; 5-Methyl-4,5,6,7-tetrahydroindazole-3-carboxylic acid ethyl ester; Ethyl 5-methyl-1,4,5,6,7,8-hexahydroindazole-3-carboxylate; 1H-Indazole-3-carboxylic acid, 4,5,6,7-tetrahydro-5-methyl-, ethyl ester
EINECS	Contact for details

Quality Control

Our 5-Methyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid ethyl ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.