Description

1H-Indazole, 5-Azido-3-Iodo- is a specialized, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both azido and iodo functional groups, makes it a versatile precursor for click chemistry and cross-coupling reactions. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and development of novel active compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of complex indazole-based drug candidates targeting various therapeutic areas.
• Click Chemistry Reagent: The azido group enables efficient, high-yielding Huisgen 1,3-dipolar cycloaddition reactions with alkynes to form triazole linkages.
• Cross-Coupling Substrate: The iodo substituent serves as an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira, Heck) to introduce diverse molecular fragments.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides with potential new modes of action.
• Material Science: Serves as a functional monomer or cross-linker in the development of advanced polymers and smart materials.
• Bioconjugation: Facilitates the site-specific labeling of biomolecules (proteins, peptides, nucleic acids) for diagnostic and imaging applications.

Basic Information

Product Name	1H-Indazole, 5-Azido-3-Iodo-
CAS No.	876365-97-8
Molecular Formula	C7H4IN5
Molecular Weight	300.04 g/mol
Synonyms	5-Azido-3-iodo-1H-indazole; 3-Iodo-5-azido-1H-indazole; 5-Azido-3-iodoindazole; 876365-97-8; 1H-Indazole, 5-azido-3-iodo-; 5-Azido-3-iodo-1H-indazole; Azido-iodo indazole derivative
EINECS	Contact for details

Quality Control

Every batch of 1H-Indazole, 5-Azido-3-Iodo- is manufactured and tested under strict quality management protocols to ensure consistency and purity for research and development applications. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer (typically -20°C) under an inert atmosphere (e.g., nitrogen or argon) to minimize decomposition due to oxidation and thermal instability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.