Description

Revefenacin is a long-acting muscarinic antagonist (LAMA) specifically developed for the maintenance treatment of chronic obstructive pulmonary disease (COPD). Its primary value lies in providing sustained bronchodilation, helping to improve lung function and reduce the frequency of COPD exacerbations. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers developing innovative inhalation therapies, including dry powder inhalers and nebulizer solutions, targeting the global respiratory disease market.

Application

• Primary Pharmaceutical Ingredient: As the key API in long-acting maintenance treatments for chronic obstructive pulmonary disease (COPD).
• Dry Powder Inhaler (DPI) Formulations: Incorporated into carrier-based blends for unit-dose or multi-dose DPI devices.
• Nebulized Solution Formulations: Used in the production of aqueous solutions for use with jet or mesh nebulizers.
• Respiratory Drug Development: Serves as a critical component in R&D for new combination therapies and next-generation delivery systems.
• Precision Medicine: Potential use in targeted therapies for patient subgroups with specific respiratory phenotypes.

Basic Information

Product Name	Revefenacin
CAS No.	876296-47-8
Molecular Formula	C24H30N2O3S
Molecular Weight	426.58 g/mol
Synonyms	TD-4208; (1R,2R,4S)-5-[(2-Phenylacetyl)oxy]-2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane methanesulfonate; Revefenacin methanesulfonate; YUPELRI (brand name formulation); LAMA (Therapeutic Class); Long-acting muscarinic antagonist
EINECS	Contact for details

Quality Control

Our Revefenacin is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical development and manufacturing. A comprehensive Certificate of Analysis (COA) is supplied with each batch, detailing purity, identity, and impurity profiles as per agreed specifications. Our quality commitment aligns with ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity: ≤0.5% Total impurities: ≤2.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.