Description

Thiophene-2-Carboxylic Acid Methyl Ester-5-Boric Acid is a high-purity, multi-functional organoboron building block and synthetic intermediate. This compound is valued for its unique chemical structure, which combines a thiophene ester moiety with a boronic acid/ester functionality, enabling versatile cross-coupling reactions and molecular construction. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions for constructing complex drug candidates, particularly those containing heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the thiophene ring can impart specific biological activity.
• Material Science Research: Serves as a precursor for the development of organic electronic materials, such as conductive polymers, OLEDs, and sensors, leveraging the thiophene unit's electronic properties.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and bioconjugates, where the boronic acid group can be used for labeling or as a recognition element.
• Academic & Contract Research: An essential reagent for methodological development in organic synthesis and catalysis research within university and CRO laboratories.

Basic Information

Product Name	Thiophene-2-Carboxylic Acid Methyl Ester-5-Boric Acid
CAS No.	876189-21-8
Molecular Formula	C8H9BO4S
Molecular Weight	212.03 g/mol
Synonyms	5-Borono-2-thiophenecarboxylic acid methyl ester; Methyl 5-boronothiophene-2-carboxylate; Methyl 5-boronothiophene-2-carboxylate; 2-Thiophenecarboxylic acid, 5-borono-, methyl ester; Methyl 5-boronylthiophene-2-carboxylate; Thiophene-2-methyl carboxylate-5-boronic acid; 5-Boronothiophene-2-methyl carboxylate
EINECS	Contact for details

Quality Control

Every batch of Thiophene-2-Carboxylic Acid Methyl Ester-5-Boric Acid is produced and tested under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality system is designed to support cGMP and ISO-guided manufacturing for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.