Description

7-Bromo-5-Trifluoromethyl-1H-Indole is a high-value halogenated indole derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and trifluoromethyl substituents, makes it an essential intermediate for creating novel compounds with tailored electronic and steric properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and receptor modulator programs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and specialty polymers due to its electron-withdrawing characteristics.
• Chemical Biology Probes: Acts as a core structure for developing fluorescent tags and molecular probes for biochemical assays and imaging.
• Cross-Coupling Reactions: The bromine atom serves as an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings to construct complex molecular architectures.

Basic Information

Product Name	7-Bromo-5-Trifluoromethyl-1H-Indole
CAS No.	875306-23-3
Molecular Formula	C9H5BrF3N
Molecular Weight	264.04 g/mol
Synonyms	7-Bromo-5-(trifluoromethyl)-1H-indole; 5-Trifluoromethyl-7-bromoindole; 1H-Indole, 7-bromo-5-(trifluoromethyl)-; 7-Bromo-5-trifluoromethylindole; 875306-23-3; 7-Br-5-CF3-1H-Indole; 7-Bromo-5-(trifluoromethyl)indole
EINECS	Contact for details

Quality Control

Our 7-Bromo-5-Trifluoromethyl-1H-Indole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.