Description

(α-S)-n-Methyl-α-[[(2S)-2-Piperidinylcarbonyl]Amino]-1H-Indole-3-Propanamide is a high-purity, chiral indole derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or a potential pharmacophore in the design of novel therapeutic agents. It is primarily sought after by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in medicinal chemistry and drug discovery programs. The precise stereochemistry and functional groups make it a valuable building block for targeting specific biological pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Protease Inhibitor Development: The structural motif suggests potential application in the design of inhibitors for specific protease enzymes.
• Peptidomimetic Synthesis: Acts as a constrained, non-natural amino acid analog in the creation of peptidomimetics with enhanced metabolic stability.
• Biochemical Tool Compound: May be utilized in vitro to study receptor-ligand interactions or enzyme mechanisms in biochemical assays.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(α-S)-n-Methyl-α-[[(2S)-2-Piperidinylcarbonyl]Amino]-1H-Indole-3-Propanamide
CAS No.	875151-71-6
Molecular Formula	C19H26N4O2
Molecular Weight	342.44 g/mol
Synonyms	(S)-N-Methyl-α-[[(2S)-2-piperidinylcarbonyl]amino]-1H-indole-3-propanamide; (2S)-1-[[(2S)-2-[[2-(1H-Indol-3-yl)-1-methyl-2-oxoethyl]amino]-2-oxoethyl]carbonyl]piperidine; (S)-N-Methyl-α-((S)-pipecolamido)-1H-indole-3-propionamide; CAS 875151-71-6; L-α-((S)-Pipecolamido)-N-methylindole-3-propionamide; Chiral Indole-3-propanamide Derivative
EINECS	Contact for details

Quality Control

Our (α-S)-n-Methyl-α-[[(2S)-2-Piperidinylcarbonyl]Amino]-1H-Indole-3-Propanamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet the stringent requirements for research use. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.