Description

5-Chloro-2-(Trifluoromethoxy)Benzylalcohol (CAS NO 874821-52-0) is a versatile fluorinated benzyl alcohol derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, combining chloro and trifluoromethoxy substituents, makes it a valuable intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a substituted benzyl alcohol moiety with enhanced lipophilicity and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), contributing to improved performance and stability.
• Organic Synthesis Building Block: A versatile reagent for constructing complex aromatic systems in medicinal chemistry and material science research programs.
• Cross-Coupling Reactions: The benzyl alcohol group can be functionalized or used in palladium-catalyzed cross-coupling reactions to create diverse biaryl structures.

Basic Information

Product Name	5-Chloro-2-(Trifluoromethoxy)Benzylalcohol
CAS No.	874821-52-0
Molecular Formula	C8H6ClF3O2
Molecular Weight	226.58 g/mol
Synonyms	(5-Chloro-2-(trifluoromethoxy)phenyl)methanol; 1-(5-Chloro-2-(trifluoromethoxy)phenyl)methanol; 5-Chloro-α-(trifluoromethoxy)benzyl alcohol; 2-(Trifluoromethoxy)-5-chlorobenzyl alcohol; Benzyl alcohol, 5-chloro-2-(trifluoromethoxy)-; 874821-52-0
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-(Trifluoromethoxy)Benzylalcohol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can accommodate custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.