Description

Toceranib Phosphate CAS NO 874819-74-6 is a potent and selective small-molecule tyrosine kinase inhibitor, specifically targeting receptor tyrosine kinases involved in oncogenic signaling pathways. This compound is of significant commercial and research interest for its targeted therapeutic action. It is primarily utilized in the pharmaceutical and veterinary pharmaceutical industries for the development and manufacturing of advanced oncology treatments.

Application

• Veterinary Oncology Drug: Active pharmaceutical ingredient (API) in the formulation of targeted cancer therapies for companion animals, most notably for the treatment of canine mast cell tumors.
• Pharmaceutical Research & Development: Critical reference standard and biochemical tool for studying tyrosine kinase inhibition mechanisms, signal transduction, and tumor biology in preclinical models.
• Human Oncology Research: Investigational compound for evaluating the potential of VEGFR, PDGFR, and Kit inhibition in various human cancer cell lines and xenograft studies.
• API Synthesis: Serves as a key intermediate or final bulk active substance in cGMP-compliant manufacturing processes for finished dosage forms.
• Biochemical Assay Development: Used to develop and validate high-throughput screening assays for kinase activity and inhibitor potency profiling.

Basic Information

Product Name	Toceranib Phosphate
CAS No.	874819-74-6
Molecular Formula	C26H31FN4O3 • H3PO4
Molecular Weight	584.53 g/mol (free base: 466.55 g/mol)
Synonyms	SU11654 Phosphate; Toceranib; Palladia (Veterinary Trade Name); 5-[(Z)-(5-Fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide phosphate; N-(2-Diethylaminoethyl)-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide phosphate; SU 11654; SU-11654
EINECS	Contact for details

Quality Control

Our Toceranib Phosphate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and consistency. We provide full traceability and Certificates of Analysis (COA) that detail specifications including assay (HPLC), related substances, residual solvents, and heavy metals, meeting the stringent requirements for pharmaceutical active ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤2.0%
Related Substances (HPLC)	Total impurities ≤2.0%; Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.