Description

Milbemycin Oxime is a semi-synthetic macrocyclic lactone derived from fermentation, widely recognized for its potent anthelmintic and acaricidal properties. This compound is a critical active pharmaceutical ingredient (API) for veterinary medicine, offering broad-spectrum efficacy against internal and external parasites. It is essential for manufacturers developing endectocide formulations for companion animals and livestock, ensuring animal health and productivity.

Application

• Primary active ingredient in veterinary pharmaceutical formulations for dogs and cats, including chewable tablets, spot-on solutions, and injectables.
• Key component in broad-spectrum parasiticide products, often combined with other actives like praziquantel or lufenuron.
• Used in preventative care products for heartworm disease, intestinal worms (hookworms, roundworms), and ear mites.
• Manufacturing of animal health products for livestock, targeting parasites that impact herd health and economic yield.
• Intermediate in the synthesis of more complex veterinary medicinal products.
• Active substance for research and development of new antiparasitic agents and delivery systems.

Basic Information

Product Name	Milbemycin Oxime
CAS No.	129496-10-2
Molecular Formula	C₃₁H₄₃NO₇
Molecular Weight	541.68 g/mol
Synonyms	Milbemycin Oxime; Interceptor (component); Milbemax (component); (5Z,25S)-5-[(E)-Hydroxyimino]-25-[(1R)-1-methylpropyl]-5,25-dihydro-6,28-methano-23H-pyrano[2,3-n][1]oxacyclotetracosin-23-one; 5-Oxime of Milbemycin A4; Oxime of Milbemycin A4; Milbemycin A4 Oxime; ZA-129
EINECS	Contact for details

Quality Control

Our Milbemycin Oxime is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical use. A comprehensive Certificate of Analysis (COA) is provided, detailing results for identity, assay, purity, and specified impurities. We support compliance with veterinary GMP and relevant pharmacopoeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, ensure containers are properly sealed after each use to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.