Description

5-(Pyrrolidin-1-Ylsulfonyl)Indoline is a high-purity, advanced pharmaceutical intermediate featuring a unique indoline scaffold modified with a pyrrolidine sulfonamide group. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of novel bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the research and development of new drug candidates, especially those targeting protein-protein interactions or specific enzyme families.
• Medicinal Chemistry Research: Used as a core scaffold for constructing compound libraries in high-throughput screening (HTS) campaigns to identify new lead structures.
• Protease Inhibitor Synthesis: The sulfonamide moiety makes it a valuable synthon for developing inhibitors of various proteases, which are important targets in multiple disease pathways.
• Kinase Inhibitor Development: Employed in the synthesis of potential kinase inhibitors, leveraging the indoline structure to interact with ATP-binding sites.
• Chemical Biology Probes: Utilized to create specialized molecular probes for studying biological mechanisms and target validation in cellular assays.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects undertaken by CDMOs (Contract Development and Manufacturing Organizations) for client-specific drug discovery programs.

Basic Information

Product Name	5-(Pyrrolidin-1-Ylsulfonyl)Indoline
CAS No.	874594-03-3
Molecular Formula	C12H16N2O2S
Molecular Weight	252.33 g/mol
Synonyms	5-(1-Pyrrolidinylsulfonyl)-2,3-dihydro-1H-indole; 5-(Pyrrolidine-1-sulfonyl)indoline; 1H-Indole, 5-(1-pyrrolidinylsulfonyl)-2,3-dihydro-; 5-(Pyrrolidin-1-ylsulfonyl)indoline; Indoline, 5-(pyrrolidin-1-ylsulfonyl)-; 874594-03-3; 5-Pyrrolidin-1-ylsulfonyl-indoline
EINECS	Contact for details

Quality Control

Every batch of 5-(Pyrrolidin-1-Ylsulfonyl)Indoline is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.