Description

4-(2-Chloroethylcarbamoyl)Benzeneboronic Acid is a specialized bifunctional organoboron compound that serves as a valuable synthetic intermediate. Its molecular architecture, combining a boronic acid moiety with a chloroethylcarbamoyl linker, makes it a versatile building block for constructing complex molecules via cross-coupling and amide bond formation. This high-purity reagent is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly in the development of targeted therapies and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds targeting specific enzymes or receptors.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic acid functional group enables efficient carbon-carbon bond formation with aryl halides, crucial for constructing biaryl structures in drug discovery.
• Proteolysis-Targeting Chimera (PROTAC) Development: Used as a linker component to conjugate E3 ligase ligands with target protein binders, facilitating targeted protein degradation.
• Bioconjugation and Labeling Reagents: Employed to attach chemical probes, fluorophores, or other functional groups to biomolecules for diagnostic or research purposes.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of advanced polymeric materials with specific functionalities.
• Agrochemical Synthesis: An intermediate in the research and development of novel herbicides or plant growth regulators with improved selectivity.

Basic Information

Product Name	4-(2-Chloroethylcarbamoyl)Benzeneboronic Acid
CAS No.	874460-05-6
Molecular Formula	C9H11BClNO3
Molecular Weight	227.45 g/mol
Synonyms	4-(2-Chloroethylcarbamoyl)phenylboronic acid; [4-[(2-Chloroethyl)carbamoyl]phenyl]boronic acid; Benzeneboronic acid, 4-[(2-chloroethyl)carbamoyl]-; 4-Carbamoylbenzeneboronic acid 2-chloroethylamide; B-[4-[(2-Chloroethyl)aminocarbonyl]phenyl]boronic acid
EINECS	Contact for details

Quality Control

Our 4-(2-Chloroethylcarbamoyl)Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and elemental analysis, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation. Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.