Description

1-Cyclohexyl-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)urea is a high-value, functionalized organic compound that serves as a critical synthetic intermediate. Its core value lies in the combination of a urea pharmacophore with a protected boronic ester functional group, enabling its use in advanced cross-coupling reactions and medicinal chemistry research. This product is essential for pharmaceutical R&D scientists and fine chemical manufacturers engaged in the development of novel bioactive molecules, particularly in kinase inhibitor and targeted therapy programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for targeted cancer therapies and kinase inhibitors.
• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester moiety serves as a versatile handle for palladium-catalyzed carbon-carbon bond formation with aryl halides.
• Medicinal Chemistry & SAR Studies: Used to explore structure-activity relationships by introducing the cyclohexyl-urea motif into molecular scaffolds.
• Chemical Biology Probe Development: Utilized in creating molecular probes to study biological pathways and protein function.
• Advanced Material Synthesis: Potential intermediate for creating functional organic materials with specific electronic or binding properties.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and library production.

Basic Information

Product Name	1-Cyclohexyl-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)urea
CAS No.	874297-81-1
Molecular Formula	C19H29BN2O3
Molecular Weight	344.26 g/mol
Synonyms	1-Cyclohexyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 4-(1-Cyclohexyl-3-ureido)phenylboronic acid pinacol ester; Urea, N-cyclohexyl-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; [4-[[(Cyclohexylamino)carbonyl]amino]phenyl]boronic acid pinacol ester; B-[4-[(Cyclohexylcarbamoyl)amino]phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Cyclohexyl-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)urea is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.