Description

Fevipiprant is a potent and selective antagonist of the prostaglandin D2 receptor 2 (DP2/CRTH2), representing a significant advancement in targeted therapeutic research. This compound is crucial for the development of novel anti-inflammatory and anti-allergic treatments, offering a mechanism of action distinct from corticosteroids. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of advanced drug candidates for respiratory and allergic diseases.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced investigational drugs targeting the DP2/CRTH2 pathway.
• Respiratory Disease Research: Used in preclinical and clinical research for developing treatments for severe asthma and chronic obstructive pulmonary disease (COPD).
• Allergic Condition R&D: Applied in studies for allergic rhinitis, atopic dermatitis, and other IgE-mediated allergic disorders.
• Mechanistic Studies: Serves as a critical reference standard and tool compound for studying prostaglandin D2 signaling in immunology and inflammation.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing of high-value, complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Fevipiprant
CAS No.	872365-14-5
Molecular Formula	C24H22N2O4S
Molecular Weight	434.51 g/mol
Synonyms	NVP-QAW039; QAW039; 2-[2-(4-Chlorobenzyl)-3-oxo-5,6-dihydro-4H-thieno[3,2-c]pyrrol-6-yl]-N-[2-(methylsulfonyl)phenyl]acetamide; (R)-2-(2-(4-Chlorobenzyl)-3-oxo-5,6-dihydro-4H-thieno[3,2-c]pyrrol-6-yl)-N-(2-(methylsulfonyl)phenyl)acetamide; CRTH2 Antagonist; DP2 Antagonist; Fevipiprant (QAV680)
EINECS	Contact for details

Quality Control

Our Fevipiprant is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. We provide comprehensive analytical data, including HPLC chromatograms and NMR spectra, to verify identity and purity. A Certificate of Analysis (COA) detailing specific test results is available with every shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.