Description

1-Isoquinolineacetic Acid,1,2,3,4-Tetrahydro-,1-Methylethyl Ester,(1R)- is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its value lies in its role as a key building block for constructing complex molecules with specific stereochemistry, which is critical for developing new active pharmaceutical ingredients (APIs). This compound, CAS 872087-96-2, is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug discovery.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to introduce the tetrahydroisoquinoline scaffold with high enantiomeric purity.
• Agrochemical Research: Serves as a precursor in the development of new, more selective pesticides and herbicides.
• Ligand and Catalyst Development: The structural motif can be incorporated into novel chiral ligands for metal-catalyzed transformations.
• Academic & Institutional R&D: Utilized in universities and research institutes for methodological studies and exploring new chemical spaces in organic chemistry.
• Process Chemistry Optimization: Employed in scaling up synthetic routes from laboratory to pilot plant scale for potential commercial manufacturing.

Basic Information

Product Name	1-Isoquinolineacetic Acid,1,2,3,4-Tetrahydro-,1-Methylethyl Ester,(1R)-
CAS No.	872087-96-2
Molecular Formula	C15H19NO2
Molecular Weight	245.32 g/mol
Synonyms	(1R)-1,2,3,4-Tetrahydro-1-isoquinolineacetic Acid 1-Methylethyl Ester; (R)-1,2,3,4-Tetrahydroisoquinoline-1-acetic Acid Isopropyl Ester; (R)-Isopropyl 1,2,3,4-Tetrahydro-1-isoquinolineacetate; (R)-1-Isopropyl 1,2,3,4-Tetrahydroisoquinoline-1-carboxylate; (R)-Tetrahydroisoquinoline-1-acetic Acid Isopropyl Ester; (R)-1-(Isopropoxycarbonylmethyl)-1,2,3,4-tetrahydroisoquinoline; (R)-1-Carboxyisopropyl-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our 1-Isoquinolineacetic Acid,1,2,3,4-Tetrahydro-,1-Methylethyl Ester,(1R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), enantiomeric excess (typically ≥99% ee), and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.