Description

(2,5-Difluoropyridin-3-Yl)Boronic Acid is a high-value boronic acid derivative and a versatile building block in modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, scalable synthesis of fluorinated pyridine-based molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides that leverage the metabolic stability and bioavailability imparted by the difluoropyridine moiety.
• Ligand & Catalyst Development: Serves as a building block for constructing sophisticated ligands used in catalysis and molecular recognition.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors for OLEDs and OFETs, due to its ability to form conjugated systems.
• Chemical Biology & Probe Design: Utilized in creating molecular probes and bioconjugates for studying biological processes and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis organizations (CSOs) and CDMOs serving the global life sciences industry.

Basic Information

Product Name	(2,5-Difluoropyridin-3-Yl)Boronic Acid
CAS No.	872041-95-7
Molecular Formula	C5H4BF2NO2
Molecular Weight	158.90 g/mol
Synonyms	3-Borono-2,5-difluoropyridine; 2,5-Difluoropyridine-3-boronic acid; (2,5-Difluoro-3-pyridinyl)boronic acid; 2,5-Difluoro-3-pyridineboronic acid; B-(2,5-Difluoropyridin-3-yl)boronic acid; 872041-95-7; (2,5-Difluoro-3-pyridyl)boronic acid
EINECS	Contact for details

Quality Control

Every batch of (2,5-Difluoropyridin-3-Yl)Boronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling reactions. A detailed Certificate of Analysis (COA) is available for each lot, confirming identity, purity (typically ≥95% by HPLC/NMR), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) for long-term storage and when dispensing to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.