Description

2-Boc-1,2,3,4-Tetrahydroisoquinoline-5-Carboxylic Acid is a high-purity, protected amino acid derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting neurological and cardiovascular disorders.
• Peptidomimetic Chemistry: Used to incorporate the tetrahydroisoquinoline scaffold into peptide analogs to enhance stability and bioactivity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for high-throughput screening.
• Agrochemical Synthesis: Serves as a building block for developing novel pesticides and herbicides with specific mode-of-action profiles.
• Chemical Biology Probes: Utilized in the development of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke intermediates at scale.

Basic Information

Product Name	2-Boc-1,2,3,4-Tetrahydroisoquinoline-5-Carboxylic Acid
CAS No.	872001-50-8
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	5-Carboxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid; 2-Boc-5-carboxy-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-2-[(1,1-dimethylethoxy)carbonyl]-5-isoquinolinecarboxylic acid; 2-Boc-Tic-OH; Boc-Tic-OH; 2-N-Boc-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-Boc-1,2,3,4-Tetrahydroisoquinoline-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.