Description

2-Thiophenecarbonitrile, 3-[4-[(1R)-1-Aminoethyl]Phenyl]- is a high-value chiral intermediate featuring a thiophene-carbonitrile core linked to a substituted phenyl ring with a specific (R)-aminoethyl group. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceutical agents, particularly in the development of targeted therapies. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the creation of novel active pharmaceutical ingredients (APIs) and fine chemicals for the life sciences sector.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for small molecule therapeutics.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Chemical Research: Used in academic and industrial R&D for exploring new chemical entities and reaction pathways in medicinal chemistry.
• Fine Chemical Production: Employed in the manufacture of high-purity, specialized fine chemicals for advanced applications.
• Ligand and Catalyst Development: Potential use in the synthesis of novel ligands or organocatalysts due to its unique heterocyclic and chiral structure.

Basic Information

Product Name	2-Thiophenecarbonitrile, 3-[4-[(1R)-1-Aminoethyl]Phenyl]-
CAS No.	871720-12-6
Molecular Formula	C13H12N2S
Molecular Weight	228.31 g/mol
Synonyms	3-[4-[(1R)-1-Aminoethyl]phenyl]thiophene-2-carbonitrile; (R)-3-(4-(1-Aminoethyl)phenyl)thiophene-2-carbonitrile; 3-[4-[(1R)-1-Aminoethyl]phenyl]-2-thiophenecarbonitrile; 2-Cyano-3-[4-[(1R)-1-aminoethyl]phenyl]thiophene; 871720-12-6; (R)-3-(4-(1-Aminoethyl)phenyl)-2-cyanothiophene; 3-(4-((R)-1-Aminoethyl)phenyl)thiophene-2-carbonitrile
EINECS	Contact for details

Quality Control

Our 2-Thiophenecarbonitrile, 3-[4-[(1R)-1-Aminoethyl]Phenyl]- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.