Description

3-Bromo-Fluorophenylmercaptan is a versatile organosulfur building block characterized by the presence of both bromine and fluorine substituents on a thiophenol core. This compound is highly valued for its dual functionality, where the bromine atom serves as an excellent site for cross-coupling reactions, and the thiol group acts as a potent nucleophile or ligand precursor. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for synthesizing novel active ingredients and advanced intermediates. Its unique structure makes it a critical reagent for introducing sulfur-containing motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly those containing aryl thioether or disulfide linkages.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that require halogenated phenylmercaptan motifs.
• Ligand Precursor in Catalysis: Serves as a starting material for creating specialized ligands used in transition metal-catalyzed reactions.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent enables Suzuki, Stille, and other palladium-catalyzed coupling reactions to form biaryl structures.
• Bioconjugation Chemistry: The thiol group can be used for site-specific modification of proteins, peptides, and other biomolecules.

Basic Information

Product Name	3-Bromo-Fluorophenylmercaptan
CAS No.	871353-12-7
Molecular Formula	C6H4BrFS
Molecular Weight	207.06 g/mol
Synonyms	3-Bromo-fluorobenzenethiol; 1-Bromo-3-fluoro-4-mercaptobenzene; (3-Bromo-4-fluorophenyl)thiol; 3-Bromo-4-fluorothiophenol; 4-Fluoro-3-bromobenzenethiol; 3-Bromo-4-fluorobenzenethiol; 3-Bromo-4-fluoro-benzenethiol
EINECS	Contact for details

Quality Control

Our 3-Bromo-Fluorophenylmercaptan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of fine chemical and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We are committed to supporting our clients' quality and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. This material is easily oxidized (store under inert atmosphere). Keep away from strong oxidizing agents and bases. The storage area should be cool, dry, and well-ventilated.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.