Description

5-Cyano-1H-Indole-2-Boronic Acid is a high-value, multi-functional boronic acid derivative essential for modern synthetic chemistry. Its core value lies in its dual functionality, serving as a versatile building block for constructing complex heterocyclic scaffolds through cross-coupling reactions. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Research: Used to create advanced heterocyclic compounds with potential herbicidal, fungicidal, or insecticidal activity.
• Material Science: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to the indole core's electronic properties.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) agents targeting specific enzymes or biological pathways.
• Academic & Contract Research: A vital reagent for methodological development in organic synthesis and catalysis research within university and CRO laboratories.
• Ligand Synthesis: Used to prepare sophisticated bidentate or tridentate ligands for transition metal catalysis.

Basic Information

Product Name	5-Cyano-1H-Indole-2-Boronic Acid
CAS No.	871329-64-5
Molecular Formula	C9H7BN2O2
Molecular Weight	186.98 g/mol
Synonyms	5-Cyano-1H-indole-2-boronic acid; (5-Cyano-1H-indol-2-yl)boronic acid; 2-Borono-5-cyanoindole; 5-Cyanoindole-2-boronic acid; 871329-64-5; 5-CN-1H-Indole-2-B(OH)2; 5-Cyano-2-indoleboronic acid
EINECS	Contact for details

Quality Control

Our 5-Cyano-1H-Indole-2-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Boronic Acid Assay (NMR)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.