Description

2-Cyclohexyl-1-(4'-Trifluoromethylbiphenyl-4-Yl)Ethanol CAS NO 871250-38-3 is a high-value, non-steroidal biphenyl ethanol derivative characterized by its unique trifluoromethyl-substituted aromatic system. This compound is a critical advanced intermediate in modern pharmaceutical synthesis, offering a versatile chiral scaffold for the development of novel therapeutic agents. It is primarily sought after by R&D departments and production facilities in the pharmaceutical and fine chemical industries engaged in creating next-generation anti-inflammatory and analgesic drugs.

Application

• Key chiral intermediate in the synthesis of novel non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 inhibitors.
• Building block for advanced pharmaceutical research targeting prostaglandin receptors and other inflammatory pathways.
• Precursor in the development of high-potency active pharmaceutical ingredients (APIs) with improved metabolic stability, owing to the trifluoromethyl group.
• Versatile scaffold for medicinal chemistry exploration in central nervous system (CNS) and autoimmune disorder therapeutics.
• Used in process chemistry for scale-up and optimization of synthetic routes for complex drug candidates.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	2-Cyclohexyl-1-(4'-Trifluoromethylbiphenyl-4-Yl)Ethanol
CAS No.	871250-38-3
Molecular Formula	C21H23F3O
Molecular Weight	348.41 g/mol
Synonyms	2-Cyclohexyl-1-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]ethanol; 2-Cyclohexyl-1-(4'-trifluoromethyl-1,1'-biphenyl-4-yl)ethanol; 1-(4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-yl)-2-cyclohexylethanol; [1,1'-Biphenyl]-4-ethanol, 2-cyclohexyl-1-[4'-(trifluoromethyl)-]; Biphenyl Ethanol Derivative (CAS 871250-38-3); Trifluoromethyl Biphenyl Ethanol Intermediate; α-Cyclohexyl-4'-(trifluoromethyl)biphenyl-4-methanol
EINECS	Contact for details

Quality Control

Our 2-Cyclohexyl-1-(4'-Trifluoromethylbiphenyl-4-Yl)Ethanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and structural identity. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our processes are designed to meet the stringent requirements of cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.