Description

1H-Benzimidazole-5-Sulfonamide, 2-[(3,4-Dihydro-2(1H)-Isoquinolinyl)Methyl]-1-Ethyl-N,n-Dimethyl- CAS NO 870757-46-3 is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of proprietary drug candidates, particularly those targeting neurological and cardiovascular pathways.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new benzimidazole-derived bioactive molecules.
• API Synthesis: Serves as a core scaffold for constructing complex molecules with potential enzyme inhibitory or receptor modulation activity.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Biochemical Research: Employed as a tool compound in biochemical assays to study specific protein-ligand interactions.

Basic Information

Product Name	1H-Benzimidazole-5-Sulfonamide, 2-[(3,4-Dihydro-2(1H)-Isoquinolinyl)Methyl]-1-Ethyl-N,n-Dimethyl-
CAS No.	870757-46-3
Molecular Formula	C21H26N4O2S
Molecular Weight	398.52 g/mol
Synonyms	2-[(3,4-Dihydro-2(1H)-Isoquinolinyl)Methyl]-1-Ethyl-N,n-Dimethyl-1H-Benzimidazole-5-Sulfonamide; 1-Ethyl-2-[(1,2,3,4-tetrahydroisoquinolin-2-yl)methyl]-N,N-dimethyl-1H-benzimidazole-5-sulfonamide; UNII-9Q2I2P8H4J; Benzimidazole sulfonamide derivative; Tetrahydroisoquinoline benzimidazole
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. We support custom synthesis and can tailor specifications to meet specific project needs, including compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, it should be kept under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.