Description

tert-Butyl 4-Chloro-2-(Hydroxymethyl)-1H-Indole-1-Carboxylate is a high-value, protected indole derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its molecular architecture, featuring both a reactive hydroxymethyl group and a chloro substituent on the indole core, makes it indispensable for constructing complex heterocyclic frameworks. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a precursor for functionalized polymers and advanced organic electronic materials.
• Academic & Contract Research: Essential reagent in university and CRO laboratories for methodological development and heterocyclic chemistry studies.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and dyes.

Basic Information

Product Name	tert-Butyl 4-Chloro-2-(Hydroxymethyl)-1H-Indole-1-Carboxylate
CAS No.	870535-27-6
Molecular Formula	C14H16ClNO3
Molecular Weight	281.73 g/mol
Synonyms	1-Boc-4-chloro-2-(hydroxymethyl)indole; 1-(tert-Butoxycarbonyl)-4-chloro-2-(hydroxymethyl)-1H-indole; 4-Chloro-2-(hydroxymethyl)-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 4-chloro-2-(hydroxymethyl)indole-1-carboxylate; 1H-Indole-1-carboxylic acid, 4-chloro-2-(hydroxymethyl)-, 1,1-dimethylethyl ester; Boc-4-Cl-2-CH2OH-indole; 870535-27-6
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Chloro-2-(Hydroxymethyl)-1H-Indole-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.