Description

[2-(2-Chloro-Acetylamino)-Thiazol-5-Yl]-Acetic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific thiazole-acetate ester structure. This compound is of critical importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular frameworks. It is primarily needed by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug molecules, especially those containing thiazole heterocycles.
• API Synthesis: Used in the research and development of Active Pharmaceutical Ingredients (APIs) for potential therapeutic applications.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects.
• Bioconjugation & Probe Development: The reactive chloroacetyl group makes it suitable for creating conjugates or molecular probes for biochemical research.

Basic Information

Product Name	[2-(2-Chloro-Acetylamino)-Thiazol-5-Yl]-Acetic Acid Methyl Ester
CAS No.	869951-10-0
Molecular Formula	C9H9ClN2O3S
Molecular Weight	260.70 g/mol
Synonyms	Methyl 2-[(2-chloroacetamido)-1,3-thiazol-5-yl]acetate; 5-(2-Methoxy-2-oxoethyl)-N-(2-chloroacetyl)-1,3-thiazol-2-amine; 2-[(2-Chloroacetylamino)-1,3-thiazol-5-yl]acetic acid methyl ester; Methyl [2-[(2-chloroacetyl)amino]-1,3-thiazol-5-yl]acetate; Thiazole-5-acetic acid, 2-[(2-chloroacetyl)amino]-, methyl ester
EINECS	Contact for details

Quality Control

Our [2-(2-Chloro-Acetylamino)-Thiazol-5-Yl]-Acetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.