Description

Thiazole, 2-[1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2,3-Dihydro-1H-Inden-5-Yl]- is a high-value, organosilane-protected thiazole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary commercial value lies in enabling the precise construction of complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation pesticides and herbicides, where the thiazole moiety contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its conjugated thiazole structure.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.
• Academic and R&D Laboratories: Used in university and industrial research settings for methodological development and exploring new chemical reactions.

Basic Information

Product Name	Thiazole, 2-[1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2,3-Dihydro-1H-Inden-5-Yl]-
CAS No.	869725-77-9
Molecular Formula	C18H25NOSSi
Molecular Weight	331.55 g/mol
Synonyms	5-(2-(tert-Butyldimethylsilyloxy)indan-1-yl)thiazole; 2-[1-[(tert-Butyldimethylsilyl)oxy]-2,3-dihydro-1H-inden-5-yl]-1,3-thiazole; 2-(1-((tert-Butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-5-yl)thiazole; TBDMS-protected indanyl thiazole; tert-Butyldimethyl((5-(thiazol-2-yl)-2,3-dihydro-1H-inden-1-yl)oxy)silane; (1-(Thiazol-2-yl)-2,3-dihydro-1H-inden-1-yl)oxy-tert-butyldimethylsilane; 869725-77-9; TBDMS-Indanyl-Thiazole
EINECS	Contact for details

Quality Control

Our production of Thiazole, 2-[1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2,3-Dihydro-1H-Inden-5-Yl]- adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR spectroscopy (1H and 13C), and mass spectrometry for identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP compliance for pharmaceutical development, and we welcome audits and quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.