Description

6-(Trifluoromethyl)-2,3-Dihydro-1H-Inden-1-Ol CAS NO 869725-46-2 is a high-value fluorinated indanol derivative, a crucial chiral building block in advanced organic synthesis. Its importance lies in the trifluoromethyl group, which imparts unique electronic and metabolic properties to target molecules, enhancing their biological activity and physicochemical profile. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used as a precursor in the development of advanced herbicides, fungicides, and insecticides, leveraging the CF3 group for improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a scaffold for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials where fluorine incorporation is desired for stability or performance.
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a probe molecule in biochemical assays.

Basic Information

Product Name	6-(Trifluoromethyl)-2,3-Dihydro-1H-Inden-1-Ol
CAS No.	869725-46-2
Molecular Formula	C10H9F3O
Molecular Weight	202.17 g/mol
Synonyms	6-(Trifluoromethyl)-2,3-dihydro-1H-inden-1-ol; 6-(Trifluoromethyl)indan-1-ol; 1-Hydroxy-6-(trifluoromethyl)indane; (1-Hydroxy-2,3-dihydro-1H-inden-6-yl)trifluoromethane; 869725-46-2; 6-Trifluoromethyl-1-indanol; 6-CF3-indan-1-ol; α-Hydroxy-6-(trifluoromethyl)indane
EINECS	Contact for details

Quality Control

Our production of 6-(Trifluoromethyl)-2,3-Dihydro-1H-Inden-1-Ol adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for pharmaceutical and advanced chemical synthesis. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment. We support compliance with cGMP, ICH Q7, and relevant regulatory frameworks for our customers' global submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e. (Specific enantiomer available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.