Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrolopyridine core. This compound is specifically engineered to serve as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly kinase inhibitors. It is essential for research and development chemists and process scale-up teams in the pharmaceutical and biotechnology sectors who require reliable, high-quality intermediates for drug discovery and manufacturing.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of targeted small molecule drugs, especially kinase inhibitors for oncology and inflammatory diseases.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization campaigns due to its versatile pyrrolopyridine scaffold.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for candidate drugs under Good Manufacturing Practice (GMP) guidelines.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for the production of clinical trial materials and commercial APIs.
• Academic Research: Utilized in university and institutional labs for the study of heterocyclic chemistry and the development of novel synthetic methodologies.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-
CAS No.	869335-19-3
Molecular Formula	C13H19ClN2OSi
Molecular Weight	282.84 g/mol
Synonyms	4-Chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrrolo[2,3-b]pyridine; 1-((2-(Trimethylsilyl)ethoxy)methyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-1H-pyrrolo[2,3-b]pyridine-1-[[2-(trimethylsilyl)ethoxy]methyl]; 4-Chloro-1-SEM-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-1-SEM-pyrrolo[2,3-b]pyridine; 869335-19-3; 4-Chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-7-azaindole
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive (hygroscopic); ensure containers are sealed under an inert atmosphere such as nitrogen or argon after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.