Description

(3Ar,9Br)-Rel-1-Boc-2,3,3A,4,5,9B-Hexahydro-1H-Pyrrolo[3,2-C]Quinoline CAS NO 868775-42-2 is a high-purity, advanced pharmaceutical intermediate featuring a complex, stereochemically defined polycyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in cutting-edge drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of complex drug candidates.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization, particularly for heterocyclic compounds.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for new chemical entities (NCEs).
• Academic Research: Utilized in university and institutional labs for methodological studies in organic synthesis and asymmetric catalysis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	(3Ar,9Br)-Rel-1-Boc-2,3,3A,4,5,9B-Hexahydro-1H-Pyrrolo[3,2-C]Quinoline
CAS No.	868775-42-2
Molecular Formula	C19H24N2O2
Molecular Weight	312.41 g/mol
Synonyms	1-Boc-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline; tert-Butyl (3aR,9bR)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-1-carboxylate; (3aR,9bR)-1-(tert-Butoxycarbonyl)-1,2,3,3a,4,5,9b-octahydropyrrolo[3,2-c]quinoline; (3aR,9bR)-1-Boc-1,2,3,3a,4,5,9b-octahydropyrrolo[3,2-c]quinoline; (3aR,9bR)-1-N-Boc-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline; BOC-protected pyrroloquinoline; Pyrrolo[3,2-c]quinoline derivative
EINECS	Contact for details

Quality Control

Our (3Ar,9Br)-Rel-1-Boc-2,3,3A,4,5,9B-Hexahydro-1H-Pyrrolo[3,2-C]Quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development with custom synthesis and scale-up services under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.