Description

7-Bromo-1H-Indole, n-Boc Protected is a high-purity, protected indole derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in providing a reactive bromine handle and a protected amine group, enabling precise and sequential functionalization for complex molecule assembly. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex heterocyclic compounds and small molecule drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel pesticides, herbicides, and fungicides that incorporate the indole scaffold.
• Peptide Mimetics & PROTACs: Serves as a versatile building block for creating peptide-like structures and Proteolysis Targeting Chimeras (PROTACs) in drug discovery.
• Material Science Research: Employed in the synthesis of organic semiconductors, dyes, and functional polymers due to its electron-rich indole core.
• Cross-Coupling Reactions: The bromine atom facilitates pivotal metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for carbon-carbon bond formation.
• Academic & R&D Laboratories: A fundamental reagent for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Item	Details
Product Name	7-Bromo-1H-Indole, n-Boc Protected
CAS No.	868561-17-5
Molecular Formula	C₁₃H₁₄BrNO₂
Molecular Weight	296.16 g/mol
Synonyms	tert-Butyl 7-bromo-1H-indole-1-carboxylate; 1-Boc-7-bromoindole; 7-Bromo-1-(tert-butoxycarbonyl)indole; 7-Bromoindole-1-carboxylic acid tert-butyl ester; N-Boc-7-bromoindole; Boc-7-Br-indole; 7-Br-1H-Indole, 1-Boc protected; 868561-17-5
EINECS	Contact for details

Quality Control

Our 7-Bromo-1H-Indole, n-Boc Protected is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.