Description

tert-Butyl (4-Bromothiophen-2-Yl)Carbamate is a high-purity, advanced pharmaceutical intermediate characterized by its bromothiophene and carbamate functional groups. This compound is of significant commercial importance as a versatile building block in the synthesis of complex organic molecules, particularly active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and fine chemical producers engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and pesticides, leveraging the thiophene moiety for biological activity.
• Material Science Research: Serves as a precursor for the development of organic semiconductors, conductive polymers, and other functional materials.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for metal-catalyzed cross-coupling reactions, which are fundamental in modern organic synthesis.
• Custom Synthesis and Scale-Up: Supplied for custom manufacturing projects, from milligram-scale research to multi-kilogram pilot plant production.

Basic Information

Product Name	tert-Butyl (4-Bromothiophen-2-Yl)Carbamate
CAS No.	868387-45-5
Molecular Formula	C9H12BrNO2S
Molecular Weight	278.17 g/mol
Synonyms	Boc-4-Bromo-2-aminothiophene; N-Boc-4-bromothiophen-2-amine; 2-Amino-4-bromothiophene, N-Boc protected; tert-Butyl N-(4-bromothiophen-2-yl)carbamate; 4-Bromo-2-((tert-butoxycarbonyl)amino)thiophene; 2-((tert-Butoxycarbonyl)amino)-4-bromothiophene; (4-Bromo-thiophen-2-yl)-carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (4-Bromothiophen-2-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.