Description

4-Amino-7-Bromoisoindolin-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique isoindolinone scaffold. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel, biologically active molecules. It is primarily required by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within oncology and CNS drug discovery pipelines.

Application

• Key synthetic intermediate for the development of PARP (Poly ADP-ribose polymerase) inhibitors used in targeted cancer therapies.
• Building block in medicinal chemistry for constructing isoindolinone-based pharmacophores with potential activity against various disease targets.
• Precursor in the research and scale-up of small molecule drug candidates, especially those requiring a brominated aromatic handle for further functionalization.
• Used in process chemistry and route scouting for the efficient, large-scale production of active pharmaceutical ingredients (APIs).
• Starting material for the synthesis of fluorescent probes or chemical sensors due to its derivatizable amino and bromo functional groups.
• Reference standard in analytical method development and quality control for pharmaceutical manufacturing.

Basic Information

Product Name	4-Amino-7-Bromoisoindolin-1-One
CAS No.	866767-08-0
Molecular Formula	C8H7BrN2O
Molecular Weight	227.06 g/mol
Synonyms	7-Bromo-1-oxo-2,3-dihydro-1H-isoindol-4-amine; 4-Amino-7-bromo-2,3-dihydro-1H-isoindol-1-one; 7-Bromo-4-aminoisoindolin-1-one; 4-Amino-7-bromoisoindolinone; 1H-Isoindol-4-amine, 7-bromo-2,3-dihydro-1-oxo-; 866767-08-0; 4-Amino-7-bromo-isoindolin-1-one
EINECS	Contact for details

Quality Control

Our 4-Amino-7-Bromoisoindolin-1-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.