Description

1H-Pyrrolo[2,3-B]Pyridine, 1-[(4-Methylphenyl)Sulfonyl]-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity, advanced pharmaceutical intermediate featuring a valuable boronic ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling key carbon-carbon bond-forming reactions like Suzuki-Miyaura cross-coupling. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester coupling partner for constructing biaryl and heterobiaryl structures central to many drug molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Chemical Biology Probes: Can be utilized to create labeled compounds for studying biological pathways and target engagement.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with complex heterocyclic cores.

Basic Information

Item	Details
Product Name	1H-Pyrrolo[2,3-B]Pyridine, 1-[(4-Methylphenyl)Sulfonyl]-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	866545-91-7
Molecular Formula	C20H23BN2O4S
Molecular Weight	398.28 g/mol
Synonyms	1-Tosyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 3-Boronic acid, 1-(p-tolylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-, pinacol ester; 1-(4-Methylbenzenesulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 866545-91-7; Tosyl-protected 3-boronic ester pyrrolopyridine
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine derivative is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical applications. Products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with customer specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch. We support development and commercial projects with quality documentation suitable for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider storing under an inert gas in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.