Description

Methyl 2-(8-Fluoro-3,4-Dihydro-1H-Pyrido[4,3-B]Indol-5(2H)-Yl)Acetate Hydrochloride is a high-purity, complex heterocyclic compound that serves as a critical advanced pharmaceutical intermediate. Its value lies in its role as a sophisticated building block for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery pipelines. This product is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in synthesizing next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of novel drug candidates targeting neurological disorders.
• Research Chemical: Used in academic and industrial research to study structure-activity relationships (SAR) of fused indole and pyridoindole derivatives.
• API Synthesis: A crucial building block in multi-step synthesis routes for complex Active Pharmaceutical Ingredients (APIs).
• Preclinical Development: Supplied to CROs and biotech firms for use in early-stage drug discovery and lead optimization programs.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in pharmaceutical manufacturing.
• Chemical Biology Probes: Utilized in the design of molecular probes to investigate specific biological pathways and protein targets.

Basic Information

Product Name	Methyl 2-(8-Fluoro-3,4-Dihydro-1H-Pyrido[4,3-B]Indol-5(2H)-Yl)Acetate Hydrochloride
CAS No.	866460-86-8
Molecular Formula	C15H18FN2O2 • HCl
Molecular Weight	310.78 g/mol (free base: 274.32 g/mol)
Synonyms	8-Fluoro-1,2,3,4,5,6-hexahydropyrido[4,3-b]indol-5-ylacetic acid methyl ester hydrochloride; Methyl (8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-5-yl)acetate hydrochloride; 866460-86-8; 5H-Pyrido[4,3-b]indol-5-acetic acid, 8-fluoro-1,2,3,4-tetrahydro-, methyl ester, hydrochloride; Methyl 2-(8-fluoro-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)acetate hydrochloride
EINECS	Contact for details

Quality Control

Our production of Methyl 2-(8-Fluoro-3,4-Dihydro-1H-Pyrido[4,3-B]Indol-5(2H)-Yl)Acetate Hydrochloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.