Description

Methyl 6-Hydroxy-7-(1-Methylallyl)-5-Oxo-1,2,3,5-Tetrahydroindolizine-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex indolizine core structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for process development and scale-up activities.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing anti-inflammatory properties.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging its unique heterocyclic scaffold for bioactivity.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex indolizine-based molecular libraries for high-throughput screening.
• Process Chemistry & Scale-Up: Critical for optimizing synthetic routes and scaling production from laboratory to pilot plant and commercial manufacturing.
• Chemical Reference Standard: Supplied as a certified reference material for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	Methyl 6-Hydroxy-7-(1-Methylallyl)-5-Oxo-1,2,3,5-Tetrahydroindolizine-8-Carboxylate
CAS No.	866393-52-4
Molecular Formula	C14H17NO4
Molecular Weight	263.29 g/mol
Synonyms	Methyl 6-hydroxy-7-(1-methylallyl)-5-oxo-1,2,3,5-tetrahydro-8H-indolizine-8-carboxylate; 8H-Indolizine-8-carboxylic acid, 1,2,3,5-tetrahydro-6-hydroxy-7-(1-methyl-2-propen-1-yl)-5-oxo-, methyl ester; 6-Hydroxy-7-(1-methylallyl)-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylic acid methyl ester; Indolizine derivative CAS 866393-52-4
EINECS	Contact for details

Quality Control

Our production of Methyl 6-Hydroxy-7-(1-Methylallyl)-5-Oxo-1,2,3,5-Tetrahydroindolizine-8-Carboxylate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.