Description

Methyl 1-[(4-Methoxyphenyl)Sulfonyl]-1H-Indole-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key synthetic building block in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Process Chemistry & Scale-Up: Serves as a defined starting material for optimizing synthetic routes and scaling up production under GMP conditions.
• Academic & Institutional Research: Employed in university and research institute laboratories for exploratory synthesis and pharmacological screening.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and reference standards.

Basic Information

Product Name	Methyl 1-[(4-Methoxyphenyl)Sulfonyl]-1H-Indole-3-Carboxylate
CAS No.	866145-32-6
Molecular Formula	C17H15NO5S
Molecular Weight	345.37 g/mol
Synonyms	1-(4-Methoxyphenylsulfonyl)-1H-indole-3-carboxylic acid methyl ester; Methyl 1-(4-methoxybenzenesulfonyl)-1H-indole-3-carboxylate; 1H-Indole-3-carboxylic acid, 1-[(4-methoxyphenyl)sulfonyl]-, methyl ester; 866145-32-6; Methyl 1-tosyl-1H-indole-3-carboxylate (methoxy analog); 1-(p-Methoxyphenylsulfonyl)indole-3-methyl carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 1-[(4-Methoxyphenyl)Sulfonyl]-1H-Indole-3-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and pharmaceutical intermediates, with specifications tailored to meet the rigorous demands of research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.