Description

4-Methyl-3-(1-Oxo-1,3-Dihydro-2H-Isoindol-2-Yl)Pentanoic Acid is a high-purity, non-natural amino acid derivative featuring an isoindolinone moiety, which is a key structural motif in medicinal chemistry. This compound is valued for its role as a sophisticated pharmaceutical intermediate and building block in the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Protease Inhibitor Research: Serves as a core scaffold or side-chain component in the design and development of novel protease inhibitors.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to improve potency and selectivity of drug candidates.
• Peptidomimetic Synthesis: Employed to create peptide analogs with enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying enzyme function and cellular processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Product Name	4-Methyl-3-(1-Oxo-1,3-Dihydro-2H-Isoindol-2-Yl)Pentanoic Acid
CAS No.	866144-51-6
Molecular Formula	C14H17NO3
Molecular Weight	247.29 g/mol
Synonyms	2-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoic acid; 4-Methyl-3-(1-oxoisoindolin-2-yl)pentanoic acid; 3-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoic acid; 2-(1-Oxoisoindolin-2-yl)-4-methylpentanoic acid; 4-Methyl-3-(1-oxo-1,3-dihydroisoindol-2-yl)pentanoic acid; (3R)-4-Methyl-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)pentanoic acid (for enantiomer); Valine isoindolinone derivative
EINECS	Contact for details

Quality Control

Our 4-Methyl-3-(1-Oxo-1,3-Dihydro-2H-Isoindol-2-Yl)Pentanoic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request, and custom purity grades can be supplied to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.