Description

2-[(E)-3-Pyridinylmethylidene]-2,3,4,9-Tetrahydro-1H-Carbazol-1-One is a high-purity, advanced pharmaceutical intermediate belonging to the carbazole alkaloid class. This compound is of significant interest for its role as a key synthetic building block in the research and development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex molecules for drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Organic Synthesis Building Block: Used in the construction of complex heterocyclic compounds due to its fused carbazole-pyridine structure.
• Biochemical Research: Employed in the study of enzyme inhibition and receptor binding assays as a probe or reference compound.
• Fine Chemical Production: Integral in the cGMP-compliant manufacturing of active pharmaceutical ingredients (APIs) for clinical trials.

Basic Information

Product Name	2-[(E)-3-Pyridinylmethylidene]-2,3,4,9-Tetrahydro-1H-Carbazol-1-One
CAS No.	866138-46-7
Molecular Formula	C19H16N2O
Molecular Weight	288.35 g/mol
Synonyms	(E)-2-(Pyridin-3-ylmethylene)-2,3,4,9-tetrahydro-1H-carbazol-1-one; 2-[(E)-3-Pyridylmethylene]-2,3,4,9-tetrahydro-1H-carbazol-1-one; 1H-Carbazol-1-one, 2,3,4,9-tetrahydro-2-[(1E)-3-pyridinylmethylene]-; 866138-46-7; Carbazole-1-one derivative; Pyridinylmethylidene carbazolone
EINECS	Contact for details

Quality Control

Our 2-[(E)-3-Pyridinylmethylidene]-2,3,4,9-Tetrahydro-1H-Carbazol-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to direct light should be avoided. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.