Description

2,2,2-Trifluoro-n-(5-Oxo-5,6,7,8-Tetrahydro[1,3]Dioxolo[4,5-G]Isoquinolin-8-Yl)Acetamide is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoroacetamide and fused isoquinoline-dioxole structure. This compound is critical for enabling the synthesis of novel, potent active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of next-generation therapeutics, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex heterocyclic drug candidates, especially those targeting kinase inhibition.
• Preclinical & Clinical Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• API Development: Serves as a precursor in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying enzyme function and biological pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and scale-up services for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for the exploration of new organic synthetic methodologies and novel compound libraries.

Basic Information

Product Name	2,2,2-Trifluoro-n-(5-Oxo-5,6,7,8-Tetrahydro[1,3]Dioxolo[4,5-G]Isoquinolin-8-Yl)Acetamide
CAS No.	866137-02-2
Molecular Formula	C₁₄H₁₁F₃N₂O₄
Molecular Weight	328.25 g/mol
Synonyms	8-[(2,2,2-Trifluoroacetyl)amino]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-one; 2,2,2-Trifluoro-N-(5-oxo-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-8-yl)acetamide; 5,6,7,8-Tetrahydro-8-[[(trifluoroacetyl)amino]-[1,3]dioxolo[4,5-g]isoquinolin-5-one; Trifluoroacetamide Isoquinoline Derivative; 866137-02-2; 8-Amino-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-one trifluoroacetamide
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-n-(5-Oxo-5,6,7,8-Tetrahydro[1,3]Dioxolo[4,5-G]Isoquinolin-8-Yl)Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and stored in a dark place to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.