Description

2,2,2-Trifluoro-n-(7-Hydroxy-6,7-Dihydro-5H-Indeno[5,6-D][1,3]Dioxol-5-Yl)-Acetamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique indeno-dioxole fused ring system and trifluoroacetamide moiety. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), where its specific stereochemistry and functional groups are essential for biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring complex, fluorinated molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially for central nervous system (CNS) and anti-inflammatory targets.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing complex, polycyclic molecular frameworks due to its rigid indeno-dioxole core.
• Fluorinated Compound Research: Serves as a valuable substrate for studying the effects of fluorine substitution on pharmacokinetics and metabolic stability in drug design.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Academic & Contract Research: Utilized in university and CRO settings for exploratory chemistry and process development projects.

Basic Information

Item	Details
Product Name	2,2,2-Trifluoro-n-(7-Hydroxy-6,7-Dihydro-5H-Indeno[5,6-D][1,3]Dioxol-5-Yl)-Acetamide
CAS No.	866131-56-8
Molecular Formula	C14H12F3NO4
Molecular Weight	315.25 g/mol
Synonyms	5-Acetamido-7-hydroxy-6,7-dihydro-5H-indeno[5,6-d][1,3]dioxole-2,2,2-trifluoro; 2,2,2-Trifluoro-N-(7-hydroxy-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)acetamide; Trifluoroacetamide indeno-dioxole derivative; CAS 866131-56-8; 5H-Indeno[5,6-d][1,3]dioxol-5-amine, 7-hydroxy-6,7-dihydro-N-(trifluoroacetyl)-; Advanced fluorinated indole-dioxole intermediate
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-n-(7-Hydroxy-6,7-Dihydro-5H-Indeno[5,6-D][1,3]Dioxol-5-Yl)-Acetamide is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity by HPLC, identification by spectroscopic methods, and impurity profiles are available upon request. We support compliance with ICH guidelines for impurities and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.