Description

3-[(E)-(2-Chloro-1,3-Thiazol-5-Yl)Methylidene]-1,3-Dihydro-2H-Indol-2-One is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing next-generation products.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and other specialized therapeutic areas.
• Agrochemical Research: Serves as a foundational molecule for developing new insecticides and fungicides, leveraging its thiazole and indole moieties.
• Organic Synthesis Building Block: Used in academic and industrial R&D for constructing complex heterocyclic frameworks for material science and chemical biology.
• API Development: Integral in the process development and scale-up of new active pharmaceutical ingredients requiring this specific molecular scaffold.

Basic Information

Product Name	3-[(E)-(2-Chloro-1,3-Thiazol-5-Yl)Methylidene]-1,3-Dihydro-2H-Indol-2-One
CAS No.	866050-75-1
Molecular Formula	C12H7ClN2OS
Molecular Weight	262.71 g/mol
Synonyms	(E)-3-((2-Chlorothiazol-5-yl)methylene)indolin-2-one; 3-[(2-Chloro-1,3-thiazol-5-yl)methylene]-1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 1,3-dihydro-3-[(2-chloro-5-thiazolyl)methylene]-, (3E)-; 3-(2-Chlorothiazol-5-ylmethylene)indolin-2-one; (E)-3-(2-Chlorothiazol-5-ylmethylene)indolin-2-one; 866050-75-1; 3-(2-Chloro-thiazol-5-ylmethylene)-1,3-dihydro-indol-2-one
EINECS	Contact for details

Quality Control

Our production of 3-[(E)-(2-Chloro-1,3-Thiazol-5-Yl)Methylidene]-1,3-Dihydro-2H-Indol-2-One adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment, detailing all critical specifications. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.