Description

tert-Butyl 2-(1,3-thiazol-4-ylmethyl)prop-2-enoate is a high-value chemical intermediate featuring a unique molecular architecture that combines a thiazole heterocycle with a protected acrylic ester moiety. This compound is critical for facilitating advanced synthetic transformations in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the life sciences sector for constructing complex target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to introduce the thiazole-acrylate pharmacophore, exploring structure-activity relationships (SAR).
• Peptidomimetic Synthesis: Acts as a precursor for non-peptide scaffolds that mimic peptide structure and function, useful in drug design.
• Agrochemical Development: Employed in the research and synthesis of new generation crop protection agents and herbicides.
• Material Science Precursor: Potential use in the development of specialty polymers and functional materials with tailored properties.

Basic Information

Product Name	tert-Butyl 2-(1,3-thiazol-4-ylmethyl)prop-2-enoate
CAS No.	866028-90-2
Molecular Formula	C11H15NO2S
Molecular Weight	225.31 g/mol
Synonyms	2-(Thiazol-4-ylmethyl)acrylic acid tert-butyl ester; tert-Butyl 2-((1,3-thiazol-4-yl)methyl)acrylate; 4-Thiazoleacrylic acid, α-(thiazol-4-ylmethyl)-, 1,1-dimethylethyl ester; 2-(1,3-Thiazol-4-ylmethyl)prop-2-enoic acid tert-butyl ester; tert-Butyl 3-(thiazol-4-yl)-2-methylenepropanoate; Acrylic acid, 2-((4-thiazolyl)methyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(1,3-thiazol-4-ylmethyl)prop-2-enoate is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.