Description

(R)-o-Tolyl-Cbs-Oxazaborolidine, 0.5M in Toluene is a high-purity, pre-formulated chiral oxazaborolidine catalyst solution, essential for achieving high enantioselectivity in asymmetric organic synthesis. This product matters because it offers consistent, reliable performance and eliminates the need for in-situ catalyst preparation, saving valuable R&D and production time. It is critically needed by process chemists and researchers in the pharmaceutical, agrochemical, and fine chemical industries for key transformations such as enantioselective reductions and aldol reactions.

Application

• As a chiral catalyst for the enantioselective reduction of prochiral ketones to secondary alcohols.
• Enabling asymmetric aldol reactions in the synthesis of complex pharmaceutical intermediates.
• Facilitating enantioselective Diels-Alder and other cycloaddition reactions.
• Used in process development and scale-up for Active Pharmaceutical Ingredient (API) manufacturing.
• Critical for research in asymmetric methodology development within academic and industrial laboratories.
• Production of chiral ligands and auxiliaries for further synthetic applications.

Basic Information

Product Name	(R)-o-Tolyl-Cbs-Oxazaborolidine, 0.5M in Toluene
CAS No.	865812-10-8
Molecular Formula	C18H20BNO
Molecular Weight	277.17 g/mol
Synonyms	(R)-2-Methyl-CBS-Oxazaborolidine; (R)-o-Tolyl-CBS; (R)-2-Methyl-CBS Catalyst; (R)-2-Methyl-1,3,2-oxazaborolidine, 3a,4,5,6,7,7a-hexahydro-3-phenyl-2-(2-methylphenyl)-, (3aR,7aS)-; (R)-2-Methyl-Corey-Bakshi-Shibata Catalyst; (R)-Me-CBS; (R)-o-Tolyl Corey's Catalyst; (R)-α,α-Diphenyl-2-pyrrolidinemethanol 3-Methylborane Complex
EINECS	Contact for details

Quality Control

Our (R)-o-Tolyl-Cbs-Oxazaborolidine solution is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high catalytic activity. Each lot is analyzed to confirm identity, assay, and solution integrity. A comprehensive Certificate of Analysis (COA) detailing purity, concentration, and solvent specifications is provided with every shipment, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C. The product is moisture-sensitive and easily oxidized; ensure containers are sealed properly after each use to maintain stability and catalytic performance. Keep away from heat and open flames.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (IR)	Conforms to structure
Assay (NMR)	0.45 - 0.55 M in Toluene
Purity (HPLC)	≥ 98.0% (oxazaborolidine)
Solvent Content (GC)	Toluene, balance
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.