Description

(R)-6-tert-Butyl 4A-Methyl 1-(4-Fluorophenyl)-4A,5,7,8-Tetrahydro-1H-Pyrazolo[3,4-G]Isoquinoline-4A,6(4H)-Dicarboxylate is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. Its complex, functionalized heterocyclic structure makes it a critical building block for the development of novel active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the synthesis of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of complex drug candidates, particularly in central nervous system (CNS) and oncology research.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct molecules with specific three-dimensional configurations required for biological activity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Process Chemistry Development: Used for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in API manufacturing.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	(R)-6-tert-Butyl 4A-Methyl 1-(4-Fluorophenyl)-4A,5,7,8-Tetrahydro-1H-Pyrazolo[3,4-G]Isoquinoline-4A,6(4H)-Dicarboxylate
CAS No.	864972-21-4
Molecular Formula	C25H28FN3O4
Molecular Weight	453.51 g/mol
Synonyms	(R)-6-tert-Butyl 4a-methyl 1-(4-fluorophenyl)-4a,5,7,8-tetrahydro-1H-pyrazolo[3,4-g]isoquinoline-4a,6(4H)-dicarboxylate; (4aR)-6-tert-Butyl 4a-methyl 1-(4-fluorophenyl)-4,4a,5,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinoline-4a,6-dicarboxylate; 864972-21-4; tert-Butyl (4aR)-4a-methyl-1-(4-fluorophenyl)-4,4a,5,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinoline-6-carboxylate; (R)-enantiomer of a pyrazolo-isoquinoline derivative; Chiral pyrazolo[3,4-g]isoquinoline intermediate
EINECS	Contact for details

Quality Control

Our (R)-6-tert-Butyl 4A-Methyl 1-(4-Fluorophenyl)-4A,5,7,8-Tetrahydro-1H-Pyrazolo[3,4-G]Isoquinoline-4A,6(4H)-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR, and mass spectrometry for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be sensitive to moisture and prolonged exposure to air; for long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.