Description

[(1S)-1-[(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Methyl]-2-Methylpropyl]Carbamic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and protective groups. This compound is critical for ensuring the precise synthesis and structural integrity of complex active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules, particularly those targeting specific biological pathways.
• Peptidomimetic Research: Used in the design and synthesis of peptide-like compounds for drug discovery programs in areas such as oncology and metabolic diseases.
• Chiral Synthesis: Serves as a chiral precursor for constructing molecules with defined three-dimensional configurations, essential for drug efficacy and safety.
• API Development: Integral to the process development and scale-up of new Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Protecting Group Chemistry: The tert-butyloxycarbonyl (Boc) and phthalimide (Pht) groups provide orthogonal protection for amines during complex synthetic sequences.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis projects requiring high chemical purity and reliable sourcing.

Basic Information

Product Name	[(1S)-1-[(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Methyl]-2-Methylpropyl]Carbamic Acid 1,1-Dimethylethyl Ester
CAS No.	864943-54-4
Molecular Formula	C19H24N2O4
Molecular Weight	344.41 g/mol
Synonyms	N-[(1S)-1-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-2-methylpropyl]carbamic acid tert-butyl ester; (S)-2-((2-((tert-Butoxycarbonyl)amino)-3-methylbutyl)isoindoline-1,3-dione; Boc-L-Val-Pht; N-Boc-N'-phthaloyl-L-valine; tert-Butyl ((S)-1-((1,3-dioxoisoindolin-2-yl)methyl)-2-methylpropyl)carbamate; L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-ylmethyl)-, (S)-; Valine derivative Boc-Val-Pht
EINECS	Contact for details

Quality Control

Our [(1S)-1-[(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Methyl]-2-Methylpropyl]Carbamic Acid 1,1-Dimethylethyl Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.