Description

2,2,2-Trifluoro-n-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Acetamide is a high-value boronic ester derivative, a crucial intermediate in modern synthetic chemistry. Its core value lies in enabling Suzuki-Miyaura cross-coupling reactions, a powerful method for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require reliable, high-purity building blocks for drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing trifluoromethyl and arylboronate functional groups.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aryl-boron coupling steps.
• Material Science: Serves as a precursor for creating advanced organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Research: An indispensable reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating complex molecular architectures via palladium-catalyzed cross-coupling.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry.

Basic Information

Product Name	2,2,2-Trifluoro-n-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Acetamide
CAS No.	864754-08-5
Molecular Formula	C14H17BF3NO3
Molecular Weight	315.10 g/mol
Synonyms	N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2,2,2-trifluoroacetamide; 2,2,2-Trifluoro-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline trifluoroacetamide derivative; 4-Pinacolatoboron-N-(trifluoroacetyl)aniline; 4-(Boronopinacolato)-N-(trifluoroacetyl)aniline; TFPA-BPin; Trifluoroacetamide phenylboronic acid pinacol ester. Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of our 2,2,2-Trifluoro-n-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Acetamide undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, critical for sensitive cross-coupling reactions. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent oxidation and hydrolysis of the boronic ester moiety. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.