Description

Revefenacin CAS NO 864750-70-9 is a long-acting muscarinic antagonist (LAMA) specifically developed for the maintenance treatment of chronic obstructive pulmonary disease (COPD). This active pharmaceutical ingredient (API) is valued for its high selectivity and potency in providing sustained bronchodilation. It is primarily required by pharmaceutical manufacturers and research institutions engaged in developing and producing innovative respiratory therapeutics.

Application

• Pharmaceutical API: As the key active ingredient in long-term maintenance inhalers for COPD.
• Drug Product Formulation: For the development and commercial production of metered-dose inhalers (MDIs) and other inhalation solutions.
• Clinical Research: Used in preclinical and clinical studies investigating new respiratory disease treatments.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical labs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the synthesis of finished dosage forms.
• Regulatory Submissions: Critical for compiling Chemistry, Manufacturing, and Controls (CMC) documentation for FDA, EMA, and other global health authority filings.

Basic Information

Product Name	Revefenacin
CAS No.	864750-70-9
Molecular Formula	C24H30N2O3S
Molecular Weight	426.58 g/mol
Synonyms	TD-4208; (R)-3-(1-((4-((Diethylamino)methyl)-2-methoxyphenoxy)methyl)-5-((R)-pyrrolidin-3-yl)-1H-indol-3-yl)-2,2-dimethylpropanoic acid; Revefenacin Yod; Yonsa (in combination); Yonsa Revefenacin; GSK-573719 (historical)
EINECS	Contact for details

Quality Control

Our Revefenacin is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure compliance with ICH Q7 guidelines for active pharmaceutical ingredients. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material suitable for use under cGMP conditions for commercial drug production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.10%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.