Description

Ethyl 8-Oxo-5,6,7,8-Tetrahydroisoquinoline-7-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the tetrahydroisoquinoline class of compounds. This molecule serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and oncological pathways. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, where precise chemical structure and reliable purity are paramount for successful outcomes.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of novel drug candidates, especially within the central nervous system (CNS) and oncology therapeutic areas.
• Organic Synthesis Building Block: Used in multi-step organic synthesis to construct complex nitrogen-containing heterocycles due to its reactive carboxylate and ketone functional groups.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery pipelines.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying biological pathways and enzyme functions.

Basic Information

Item	Details
Product Name	Ethyl 8-Oxo-5,6,7,8-Tetrahydroisoquinoline-7-Carboxylate
CAS No.	864499-11-6
Molecular Formula	C₁₂H₁₃NO₃
Molecular Weight	219.24 g/mol
Synonyms	Ethyl 8-oxo-5,6,7,8-tetrahydroisoquinoline-7-carboxylate; 7-Carbethoxy-8-oxo-5,6,7,8-tetrahydroisoquinoline; Ethyl 7,8-dihydro-8-oxoisoquinoline-7-carboxylate; 8-Oxo-5,6,7,8-tetrahydroisoquinoline-7-carboxylic acid ethyl ester; CAS 864499-11-6
EINECS	Contact for details

Quality Control

Our Ethyl 8-Oxo-5,6,7,8-Tetrahydroisoquinoline-7-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.