Description

5-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-4-Thiazolecarboxylic Acid is a high-purity, protected amino acid derivative featuring a thiazole heterocycle, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the controlled introduction of functionalized thiazole motifs into complex molecular architectures, which is essential for developing novel active compounds. This intermediate is particularly vital for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize potential drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides that incorporate the thiazole moiety for enhanced biological activity.
• Peptide Mimetics & Conjugation: Employed in the synthesis of peptide analogs and bioconjugates, where the Boc-protected amino group and carboxylic acid functionality allow for selective coupling and deprotection strategies.
• Material Science Research: Acts as a precursor for functionalized polymers or organic electronic materials that require specific heterocyclic components.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material or intermediate for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	5-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-4-Thiazolecarboxylic Acid
CAS No.	864436-94-2
Molecular Formula	C9H12N2O4S
Molecular Weight	244.27 g/mol
Synonyms	5-[(tert-Butoxycarbonyl)amino]-1,3-thiazole-4-carboxylic acid; 5-((tert-Butoxycarbonyl)amino)thiazole-4-carboxylic acid; 5-(Boc-amino)-4-thiazolecarboxylic acid; Boc-4-Thz-OH; 4-Thiazolecarboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-; 5-(N-Boc-amino)thiazole-4-carboxylic acid; tert-Butyl (4-carboxythiazol-5-yl)carbamate
EINECS	Contact for details

Quality Control

Our 5-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-4-Thiazolecarboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for assay and purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.