Description

Thiazole, 2-Iodo-4-(Trifluoromethyl)- is a high-value, halogenated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, combining an electron-deficient trifluoromethyl group with a reactive iodine substituent on the thiazole core, enabling precise cross-coupling and functionalization reactions. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and anti-infective agents.
• Agrochemical Research: Serves as a versatile precursor in the synthesis of new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Used in the synthesis of advanced organic electronic materials, such as charge-transport layers or light-emitting components, due to its electron-accepting properties.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Stille couplings to construct complex biaryl and conjugated systems.
• Ligand and Catalyst Development: Employed as a building block for creating novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Fluorine Chemistry Studies: Acts as a model compound for investigating the influence of the trifluoromethyl group on the reactivity and physicochemical properties of heterocycles.

Basic Information

Product Name	Thiazole, 2-Iodo-4-(Trifluoromethyl)-
CAS No.	864376-14-7
Molecular Formula	C4HF3INS
Molecular Weight	278.99 g/mol
Synonyms	2-Iodo-4-(trifluoromethyl)thiazole; 4-(Trifluoromethyl)-2-iodothiazole; 2-Iodo-4-trifluoromethylthiazole; Thiazole, 2-iodo-4-(trifluoromethyl)-; 864376-14-7; 2-Iodo-4-(trifluoromethyl)-1,3-thiazole
EINECS	Contact for details

Quality Control

Our Thiazole, 2-Iodo-4-(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.